Rejuran Healer·i·HB·S: What’s the Difference?

Hello. I’m the head doctor at Diorae Clinic, Gangnam Station.

"I heard Rejuran is good, so I looked into it, but there are so many types I don’t know which one to choose."

"What’s the difference between Healer and HB? Do I need to get Rejuran i separately?"

These are questions I hear very often in the consultation room. Rejuran is currently divided into four lineups: Healer, i, HB Plus, and S. They all use the same core ingredient, but their purpose and formulation differ. Today, I’ll clearly explain the differences between these four Rejuran products.

Rejuran: How does it regenerate the skin?

The key ingredient in Rejuran is PN (polynucleotide). It is a biocompatible substance extracted and purified from salmon DNA, and because its base composition is very similar to human DNA, it is a safe ingredient with almost no immune reaction.

When PN is injected into the dermis, it activates the adenosine A2A receptor, which in turn promotes the proliferation of fibroblasts (cells that produce collagen in the skin) and the synthesis of collagen and elastin. A study published in the 2024 issue of Journal of Cosmetic Dermatology (Lampridou et al.) also confirmed that fibroblast activity and collagen synthesis increased significantly after PN exposure.

In simple terms, Rejuran is a procedure that restores the skin’s own regenerative ability rather than filling it from the outside. This is the fundamental difference from regular fillers or Botox.

The 4 Rejuran types: A quick overview of the key differences

Rejuran Healer — The original, the most basic, and the most powerful

This is the original Rejuran, launched first and used most widely. It consists of a single PN ingredient, so it focuses entirely on skin regeneration effects.

By evenly injecting it across the entire face, it improves overall skin condition, including increased skin thickness, improved elasticity, reduced fine lines, minimized pores, and balanced oil and moisture. In a randomized controlled clinical trial involving 72 people, PN injections showed significantly higher skin elasticity and collagen density than HA fillers, and improvements in skin surface roughness and wrinkle depth were also reported.

Recommended for:

• Those who need overall facial elasticity and regeneration
• Those concerned about fine lines, pores, and dryness all at once
• Those who want to experience Rejuran’s regenerative effects in the purest form

Rejuran i — A dedicated formulation for delicate eye areas

The skin around the eyes is about 40% thinner than other areas of the face and has more blood vessels, so if regular Rejuran is injected as is, swelling marks may remain for a long time or bruising may occur easily.

Rejuran i was developed as a thin formulation with lower viscosity to solve this problem. It contains the same PN ingredient, but it is designed to spread naturally even in thin eye-area skin, with almost no risk of visible product or nodules.

In a study of 218 Asian patients, eye-area wrinkles reportedly decreased by about 61.4% at 12 weeks after PN injection, and side effects were limited to mild swelling, bruising, and pain.

Recommended for:

• Those concerned about fine lines around the eyes and dark circles
• Those worried that filler may show through because the under-eye skin is thin
• Those whose eye corners look droopy due to reduced eye-area elasticity

Rejuran HB Plus — The arrival of “painless Rejuran”

Despite Rejuran’s excellent effects, the reason many people hesitate is pain. Rejuran HB Plus is a product that directly addresses this issue.

It combines the existing PN ingredient with hyaluronic acid (HA) and the local anesthetic lidocaine. In a clinical trial involving 53 patients conducted at Seoul National University Bundang Hospital, pain immediately after the procedure was confirmed to be reduced by about 53% compared with conventional Rejuran.

With HA added, you can expect immediate hydration and a dewy effect in addition to PN’s regenerative benefits.

Recommended for:

• Those who find Rejuran painful
• Those who want regeneration and hydration at the same time
• Those who want dewy, glowing skin
• Those trying Rejuran for the first time and want to start comfortably

Rejuran S — A high-viscosity Rejuran specialized for scar improvement

The “S” in Rejuran S stands for Scar. Among the four lineups, it is a gel-type product with the highest viscosity, specialized for pitted acne scars and post-traumatic depressed scars.

Thanks to its high viscosity, after injection it acts as a 3D physical support scaffold at the base of the scar. It physically lifts surrounding tissue to immediately raise depressed areas, while during the breakdown process it induces fibroblasts to fill in new collagen.

It is generally highly synergistic when used in combination with subcision or fractional laser.

Recommended for:

• Those concerned about acne scars (boxcar, rolling, ice pick scars)
• Those who want to improve post-traumatic depressed scars
• Those who want to maximize the effects of existing scar treatments

Which Rejuran is right for me?

Overall skin condition improvement → Rejuran Healer or HB+

Focused eye-area care → Rejuran i

Sensitive to pain + dewy effect → Rejuran HB+

Improving depressed scars → Rejuran S

Of course, you don’t have to choose just one. In actual clinical practice, it is often common to combine different Rejuran types by area.

Procedure combinations that work well together

• Rejuran + Botox: PN’s regenerative effects and Botox’s wrinkle-relaxing effects create synergy, maximizing the improvement of fine lines
• Rejuran S + subcision/fractional laser: By releasing adhesions beneath the scar while inducing regeneration at the same time, it is effective for depressed scars
• Rejuran + Thermage/Ulthera: Rejuran promotes dermal regeneration, while radiofrequency/ultrasound simultaneously induces collagen contraction and lifting

Frequently asked questions (Q&A)

Q1. Can I get Rejuran even if I have a salmon allergy?

Rejuran’s PN is a highly purified and extracted ingredient from salmon DNA, with proteins (allergens) almost completely removed. However, if you have a severe salmon allergy, please be sure to inform the medical staff before the procedure.

Q2. Does swelling mark last a long time after Rejuran treatment?

Rejuran Healer and HB+ usually subside in 1~2 days, and Rejuran i also settles in 1~2 days. Rejuran S has higher viscosity, so it may take about 3~7 days.

Q3. How many sessions are needed to see Rejuran’s effects?

Even after one session, you may notice improved skin texture after about 2 weeks. For optimal results, 3 or more sessions at 2~4 week intervals are recommended.

Q4. Is Rejuran HB+ less effective than Healer?

Since the concentration of PN, the core regenerative ingredient, is the same, the skin regeneration effect itself is nearly identical. HB+ simply adds HA (hydration) and lidocaine (pain relief).

Q5. Will Rejuran S alone completely remove acne scars?

For deep scars, complete improvement with a single treatment alone is difficult to expect. The best results are achieved when combined with other scar treatments such as subcision and fractional laser.

Q6. Can all four types be done at the same time?

It is possible to combine different Rejuran types by area on the same day. We recommend determining the optimal combination through consultation before the procedure.

Closing

All four Rejuran types are based on the excellent ingredient PN, but each formulation is optimized for a different area and purpose. What matters most is choosing the right product for your skin condition and concerns, and the precise injection technique of an experienced medical professional.

If you’re wondering which Rejuran is right for you, please feel free to book a consultation. After directly assessing your skin condition, we will suggest the optimal treatment plan.

References

1. Lampridou M, et al. Increased fibroblast activity and collagen synthesis after PN exposure. J Cosmet Dermatol. 2024;23(6).
2. Rho NK, et al. A Survey on the Cosmetic Use of Injectable Polynucleotide Products Among Practitioners. J Cosmet Dermatol. 2024;23(6):1234-1242.
3. Lee KWA, et al. Polynucleotides in aesthetic medicine: a review of current practices. Int J Mol Sci. 2024;25(15):8224.
4. PDRN review paper: In a Rejuran study of 218 participants, a 61.4% reduction in eye-area wrinkles was reported after 12 weeks. Appl Sci. 2025;15(19):10437.
5. Pak CS, et al. A phase III, randomized, double-blind clinical trial: polynucleotide filler vs HA filler in crow's feet. J Korean Med Sci. 2014;29(S3):S201.