Rejuran in Korea comes in four versions, Healer, HB Plus, Eye (Rejuran i) and S, and they all use the same salmon-derived polynucleotide (PN); what changes is the texture, the target area and how much it hurts. Most visitors get the best result from one session early in their trip, choosing Healer or HB Plus for the full face, Eye for under-eye skin and S for acne scars.
This guide explains which Rejuran fits which concern, how many sessions you really need, and how to fit the downtime around flights, makeup and sightseeing in Seoul.
Planning Rejuran in Seoul? See DIORE Clinic's "Click➡️" Painless Rejuran 4cc offer on K-Beauty Station, and add your skin photo, main concern and travel dates when you book.
What Rejuran is, in one minute
Rejuran is an injectable skin booster made by PharmaResearch, a Korean company, and approved by Korea's Ministry of Food and Drug Safety. Its active ingredient, polynucleotide (PN), is a purified DNA fragment from salmon. Placed in the dermis, it supports the fibroblasts that make collagen and elastin, so the skin repairs itself rather than being filled.
That is why Rejuran is not a filler and not a lifting device. It improves texture, thickness, fine lines and glow. It does not add volume or lift sagging. As of 2026, injectable Rejuran is not FDA approved in the US, where only the skincare line is sold. For many American patients, a trip to Seoul is the practical way to get the real injection.
Rejuran Healer vs HB Plus vs Eye vs S: comparison table
In short: Healer is the original and the purest regenerating version. HB Plus adds hyaluronic acid for instant hydration and lidocaine to make it more comfortable. Eye is thinner so it spreads smoothly in delicate under-eye skin. S is the thickest gel, made to lift and rebuild pitted scars.
Which Rejuran is right for you?
Rejuran Healer: the original
Good for: dull, thin or tired skin, fine lines, enlarged pores and dryness across the whole face. In a randomized trial of 72 patients, PN injections improved skin elasticity and collagen density more than a hyaluronic acid filler.
Pair it with: Thermage FLX or Ultherapy when you also want tightening (see our lifting treatments guide).
Rejuran HB Plus: the comfortable choice
Good for: first-timers, pain-sensitive patients, and anyone who wants a dewy glow as well as repair. A Korean clinical trial with 53 patients found HB Plus cut injection pain by roughly half compared with standard Rejuran. The PN content is the same, so the repair effect is about the same as Healer.
Pair it with: skin Botox for oily skin and pores (see our Botox guide).
Rejuran Eye (Rejuran i): for the under-eye area
Good for: crepey under-eye skin, fine lines, crow's feet and shadowing from thin skin. Eye skin is far thinner than the cheeks, so a standard thick formula can leave lumps. In a study of 218 Asian patients, under-eye wrinkles improved by about 61% at 12 weeks, with only mild swelling and bruising.
Pair it with: Rejuran Healer or HB Plus on the rest of the face in the same visit.
Rejuran S: for acne scars
Good for: boxcar, rolling and post-injury depressed scars. Its thick gel acts as a scaffold under the scar while new collagen forms.
Pair it with: subcision or fractional laser. Deep scars rarely resolve with Rejuran S alone.
At DIORE: one face, more than one Rejuran. The doctor maps your face by zone rather than selling one product. A common plan is Healer or HB Plus on the cheeks and forehead, Eye under the eyes and S on scars, all in one visit. Every treatment and recovery bed at DIORE Clinic (Gangnam, Seoul) is in a private single room, so numbing, injections and soothing care happen one to one.
Best Rejuran by skin concern
In short: choose Healer for overall repair, HB Plus for comfort and hydration, Eye for the under-eye area and S for scars. Combinations are common and can be done in one visit.
How many Rejuran sessions do you need?
The standard course is three sessions, two to four weeks apart. Many people notice smoother, more hydrated skin about two to four weeks after the first session, and the full result builds over two to three months. After a complete course, results typically last 6 to 12 months.
One session is closer to a preview than a full treatment, but it still gives a visible glow. If you are in Korea for a short stay, here is how patients usually plan:
- One trip of 1 week: one session in the first two days, then decide on follow-ups for your next visit.
- A stay of 3 weeks or more: two sessions can fit, at least two weeks apart.
- Regular visitors: time each trip about one month apart, or book sessions around return trips.
At DIORE: Rejuran with Potenza or Thermage on the same day. These treatments work in different ways, so they can be combined. The order matters: devices go first and injections go last, so the PN is never exposed to device heat. With Potenza, the microchannels it creates help Rejuran reach deeper. This lets overseas patients get more done in one visit.
What does Rejuran cost in Korea?
As of 2026, public price lists in Seoul typically put Rejuran Healer at about ₩240,000 to ₩600,000 (roughly $165 to $415) per 2cc session, and Rejuran Eye at about ₩150,000 to ₩400,000 per 1cc. Prices vary with the product, the dose, and how much time the doctor spends with you. Korea is cheaper because it is where Rejuran is made and treatment volume is high, not because the product is different.
When you ask for a quote, check four things in writing: the product name (Healer, HB Plus, Eye or S), the dose in cc, the number of sessions, and whether VAT is included.
Ready to plan your Rejuran? See the "Click➡️" Diore Painless Rejuran 4cc offer, or tap the DIORE Clinic card at the top of this article.
Rejuran downtime: traveler checklist
In short: plan Rejuran early in your trip, expect small bumps for one to three days, wear light makeup from the next day, and skip the sauna for about a week. Tell the doctor about any fish or salmon allergy, pregnancy or active skin infection before treatment.
Why choose DIORE Clinic for Rejuran in Korea
DIORE Clinic (Gangnam, Seoul) is a boutique clinic near Gangnam Station and Sinnonhyeon Station, at 428 Gangnam-daero, 9th floor. It is built as the opposite of a high-volume "factory clinic."
- English-fluent medical staff. Ask anything, understand everything. An English-speaking consultation team plans your treatment, and the doctor talks you through the procedure in English.
- Honest pricing. Five-star care. Every treatment and care bed is in a private single room, with one-to-one aftercare.
- Genuine products, full dose. DIORE uses authentic Rejuran, Thermage FLX and Ultherapy products and tips at the stated dose.
- Plans built around your trip. Your plan states what to do now, what can wait for your next visit, and what you do not need.
At DIORE: see your genuine Rejuran. Ask to see the sealed product before your treatment. Checking the product name and the cc on the box is the easiest way to know you are getting exactly what you paid for, at any clinic.
Book a Rejuran consultation
When you book, add three things: a photo of your skin in natural light, your main concern, and your dates in Korea. You do not need to know which Rejuran you want.
Copy into your booking request: "Hi DIORE, I'm in Seoul from Nov 20 to 27 and interested in Rejuran for under-eye lines and dull skin. Here's a photo."
"Click➡️" Book Diore Painless Rejuran 4cc at DIORE Clinic
FAQ
How much does Rejuran cost in Korea?
In Seoul, Rejuran Healer typically costs about ₩240,000 to ₩600,000 (roughly $165 to $415) per 2cc session in 2026, often far less than abroad. Prices depend on the product, dose and clinic. Always confirm the product, cc, number of sessions and VAT in writing.
Is Rejuran painful?
Rejuran feels like many small pinches, and most people rate it around 3 to 4 out of 10 with numbing cream. Rejuran HB Plus contains lidocaine and is noticeably more comfortable, which makes it a good first choice for pain-sensitive patients.
How many Rejuran sessions do you need?
Most people need three sessions, two to four weeks apart, for the full effect, which builds over two to three months and typically lasts 6 to 12 months. One session still improves glow and texture, so travelers often start in Korea and continue on later trips.
Is Rejuran FDA approved?
No. As of 2026, injectable Rejuran is not FDA approved, so US clinics cannot offer the authentic injection; only Rejuran skincare is sold there. In Korea, where it is made, it is approved by the Ministry of Food and Drug Safety and widely used.
Rejuran HB vs Healer: which is better?
Neither is stronger, because both contain the same PN. Healer is the pure original, while HB Plus adds hyaluronic acid for hydration and lidocaine for comfort. Choose HB Plus if you dislike pain or want extra glow, and Healer if you want the classic formula.
Related DIORE guides
Medically reviewed by DIORE Clinic, Seoul.
This article is for general information only and is not a substitute for a personal medical consultation. Results, downtime and the number of sessions vary from person to person.
